Author

R. Burbano

3 papers indexed here

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Open access Oct 2026

Induced mismatch repair deficiency: a hypothesis for the transient and reversible sensitization of mismatch repair-proficient tumors to Immune checkpoint blockade

Immune checkpoint blockade (ICB) has transformed the treatment landscape of multiple malignancies, producing durable responses and long-term survival in subsets of patients with advanced cancer. However, the clinical benefit of ICB remains largely restricted to tumors displaying pre-existing immune activation, high tum...

P. Assumpção, A. Leal, W. Barra et al. · Frontiers in Immunology · 0 citations

Open access Sep 2026

Prenatal binge-like ethanol exposure induces long-lasting hippocampal oxidative stress, altered inflammatory responses, and memory impairment.

Prenatal ethanol exposure is associated with persistent neurodevelopmental abnormalities, yet the neurobiological consequences of moderate binge-like exposure remain poorly understood. This study investigated whether prenatal ethanol exposure at a moderate binge-drinking dose (3 g/kg/day) during gestational days 6-8 is...

P. F. S. Mendes, Daiane Claydes Baia-da-Silva, Vinicius Ruan Neves Dos Santos et al. · Naunyn-Schmiedeberg's Archiv... · 0 citations

Sep 2026

Early-gestational binge ethanol exposure induces persistent motor dysfunction associated with cerebellar redox and cytokine dysregulation in rat offspring.

It is demonstrated that brief binge-like EtOH exposure during early gestation is sufficient to induce persistent motor dysfunction accompanied by cerebellar redox imbalance and cytokine dysregulation, with evidence of sex-dependent behavioral susceptibility.

P. F. S. Mendes, Daiane Claydes Baia-da-Silva, Vinicius Ruan Neves Dos Santos et al. · Toxicological Sciences · 0 citations