Author

R. Baric

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Open access Oct 2026

Human lung organoid modelling of tissue-resident antiviral T cell responses.

Tissue-resident immunity constitutes a first line of defence against pathogens and enables rapid innate and adaptive memory responses1-3. However, experimental studies have been hindered by a lack of holistic human in vitro models that enable epithelial infection in the context of tissue-resident immune subsets. In lun...

J. Rathkey, Shannon S. Choi, V. van Unen et al. · Nature · 0 citations

Open access Aug 2026

Protective pan-betacoronavirus neutralizing antibodies by vaccination

These findings provide proof-of-concept that epitope-focused nanoparticle immunogens can target partially occluded, immunoquiescent bnAb epitopes, laying the groundwork for pan-betacoronavirus vaccines that provide broad protection and strengthen pandemic preparedness.

Panpan Zhou, Ziqi Feng, Wan-ting He et al. · bioRxiv · 0 citations

Aug 2026

Convergent IGHV3-53/3-66 antibodies elicited by Omicron BA.1 infection broadly neutralize emerging SARS-CoV-2 variants

G germline revertant analysis of the COV2-3731 mAb provided additional insights into how this COV2-3731 and other IGHV3-53/3-66-encoded public antibodies evolve to gain breadth against antigenically distinct SARS-CoV-2 variants such as BA.2.3.2, BA.3.1, KP.2.2, and, to some extent, KP.3.3.2.

Naveenchandra Suryadevara, Seth J. Zost, John M. Powers et al. · bioRxiv · 0 citations