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Author

R. Atarashi

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2 papers indexed here

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Open access Sep 2026

Optimization of a thermal shaker-aided quaking-induced conversion platform for the rapid detection of prion seeding activity in human samples

Creutzfeldt-Jakob disease (CJD) is a rapidly progressive, fatal neurodegenerative disorder caused by the misfolding of the normal prion protein (PrPC) into its pathogenic form (PrPSc). Therefore, effective clinical management and infection control require diagnostic assays that combine sub-attomole sensitivity with a t...

Y. Miyazaki, T. Homma, T. Nakagaki et al. · 0 citations
Open access Sep 2026

Evidence for multiple prion conformers in natural scrapie isolates

Prion strains in infected animals may exist as heterogeneous populations composed of a major prion conformer responsible for the dominant disease phenotype and minor conformers that are phenotypically silent or difficult to detect. However, the presence and biological significance of such minor conformers in natural pr...

M. Imamura, Kohtaro Miyazawa, H. Okada et al. · 0 citations

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