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Open access Oct 2026

Hepatocyte Serine Palmitoyltransferase 3 is essential for mitochondrial ceramide homeostasis and electron transport chain function.

Sphingolipids constitute essential membrane lipids that also function as signaling molecules mediating fundamental cellular processes. Disruption of constitutive sphingolipid metabolism contributes to a range of metabolic diseases. Sphingolipid biosynthesis is initiated by serine palmitoyltransferase (SPT), a heteromer...

Maryam Jamil, Anna Kovilakath, Yolander A. Valentine et al. · 0 citations
Open access Oct 2026

A telomere-to-telomere reference genome for Rosa roxburghii reveals lineage-specific diversification of triterpenoid biosynthesis

Rosa roxburghii ( RRT ) is a nutritionally and medicinally important Rosaceae species that accumulates diverse bioactive compounds, making it an excellent system for investigating the genetic basis and evolutionary diversification of specialized metabolism. Here, we report a complete telomere-to-telomere (T2T),...

Liang-Qun Li, Mei Peng, Yan-Fang Yan et al. · 0 citations

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