Qui Ngoc Sang Nguyen

Oxindole Compounds Induce NRF2-ARE Antioxidant Pathway in MCF7 Cells and Reduce Inflammatory Response in RAW264.7 Cells

Using previously reported chemical structures and synthetic methods, we prepared a series of 19 oxindole derivatives and evaluated their ability to activate the NRF2–ARE signaling pathway and induce the expression of downstream antioxidant genes. All 19 compounds activated NRF2–ARE signaling. Among them, OIC3 and OIC15...