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Open access Aug 2026

Active vitamin D protects against osteoporosis by promoting VDR-dependent CDK2 transcription and P27 degradation.

OBJECTIVE Osteoporosis is associated with reduced active vitamin D, but the molecular basis remains incompletely understood. This study investigated how active vitamin D preserves skeletal homeostasis and prevents bone loss. DESIGN Experimental mechanistic study using genetically modified mouse models and bone marrow...

Fangrong Xu, Quan Liu, Mingxin Huang et al. · 0 citations

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