Blood-brain barrier-penetrant nanotherapy inhibits haem oxygenase-1-mediated ferroptosis for post-resuscitation neuroprotection
Cardiac arrest (CA) induces global ischaemia-reperfusion (I/R) injury that results in extensive neuronal damage and high rates of mortality and cognitive impairment, yet effective neuroprotective therapies remain lacking. A major barrier to intervention is the blood-brain barrier (BBB), which restricts drug access to i...