Open access
Oct 2026
Intestinal 3-methylindole exacerbates sepsis-induced neuroinflammation through microglial NLRP3 inflammasome activation
A specific gut microbial pathway is identified and sepsis-induced expansion of Escherichia coli and its overproduction of the metabolite 3-methylindole are key aggravating factors, which contributes to a new mechanistic understanding of SAE pathogenesis.
Heng Fang, Si-Min Wu, Pei-Xian Huang et al.
· Microbiology spectrum · 0 citations