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Open access Sep 2026

Identification of CA2 as a potential candidate gene involved in the therapeutic effect of Huatan Huoxue decoction on polycystic ovary syndrome: An integrated study of network pharmacology, Mendelian randomization, and experimental validation

Purpose Huatan Huoxue decoction (HTHXD) is effective in treating polycystic ovary syndrome (PCOS); however, its underlying mechanisms of action remain unclear. Gene targets were obtained through Mendelian randomization (MR) analysis using druggable genes from public databases and genome-wide association study data for...

Chan Zhu, Yi-Jing Zhang, Pan-Wei Hu et al. · 0 citations
Review Open access Sep 2026

Programmed cell death in metabolic syndrome: From molecular mechanisms to therapeutic strategies (Review)

A comprehensive overview of recent advances in the understanding of how established and emerging forms of PCD contribute to MetS pathogenesis is provided, including apoptosis, pyroptosis, autophagy, ferroptosis, necroptosis, necroptosis, PANoptosis and disulfidptosis.

Jia-Lin Zhong, Mao-Fu Zhang, Ya-Fang Zheng et al. · 1 citation
Open access Sep 2026

Bibliometric mapping of scientific production on maturity-onset diabetes of the young: evolution, hotspots, and future directions

MODY research has evolved into a multidisciplinary field that bridges biological mechanisms, clinical characterization, and translational application, and future studies should broaden population coverage and translate molecular findings into more precise diagnosis and individualized management.

Cui-Cui Gong, Ya-Sheng Deng, Huakang Li et al. · 0 citations
Aug 2026

Environmental Endocrine Disruptors Activate CBX2 to Disrupt Cholesterol Homeostasis in PCOS.

A novel EDC-CBX2-H3K27me3 epigenetic axis that decouples GC proliferation from metabolic support functions is revealed, establishing CBX2 as both a molecular biomarker and potential therapeutic target for environment-associated PCOS.

Chan Zhu, Xian-Liang Qiu, Hong Yang et al. · 0 citations

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