Purpose Huatan Huoxue decoction (HTHXD) is effective in treating polycystic ovary syndrome (PCOS); however, its underlying mechanisms of action remain unclear. Gene targets were obtained through Mendelian randomization (MR) analysis using druggable genes from public databases and genome-wide association study data for...
Chan Zhu, Yi-Jing Zhang, Pan-Wei Hu et al.· Journal of Food and Drug Ana...· 0 citations
A comprehensive overview of recent advances in the understanding of how established and emerging forms of PCD contribute to MetS pathogenesis is provided, including apoptosis, pyroptosis, autophagy, ferroptosis, necroptosis, necroptosis, PANoptosis and disulfidptosis.
Jia-Lin Zhong, Mao-Fu Zhang, Ya-Fang Zheng et al.· International Journal of Mol...· 1 citation
MODY research has evolved into a multidisciplinary field that bridges biological mechanisms, clinical characterization, and translational application, and future studies should broaden population coverage and translate molecular findings into more precise diagnosis and individualized management.
Cui-Cui Gong, Ya-Sheng Deng, Huakang Li et al.· Orphanet Journal of Rare Dis...· 0 citations
A novel EDC-CBX2-H3K27me3 epigenetic axis that decouples GC proliferation from metabolic support functions is revealed, establishing CBX2 as both a molecular biomarker and potential therapeutic target for environment-associated PCOS.
Chan Zhu, Xian-Liang Qiu, Hong Yang et al.· Journal of Steroid Biochemis...· 0 citations
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