Qionghai Dai

Constructing mesoscale functionomics by neural dynamics subspace clustering

Function subspace clustering based on sparse Representation of Intrinsic Dynamics (FRID), an unsupervised approach for identifying neurons with shared microcircuit connectivity and information encoding properties (referred to as ‘Functionomics’) from mesoscale neural recordings significantly outperforms correlated-firing-based methods in both simulated complex networks and empirical calcium recordings.