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Open access Oct 2026

Programmable design of functional RNAs through multimodal generative learning

RNA engineering is bottlenecked by the tight coupling among sequence, structure, and function, leaving the field reliant on heuristics or screening. We introduce RNAverse, a multimodal generative model that learns a conditionable design grammar from RNA sequences, experimental structural probing profiles, and functiona...

Jian-Bo Ma, Jiang-Hui Zhu, Wen-Ze Huang et al. · 0 citations
Open access Oct 2026

Resolving cell–cell interaction networks and their molecular logic in complex tissues

CCI-seq identified known interactions and fine-grained cellular organization in mouse kidney and intestine, and uncovered aberrant interactions and disrupted spatial organization in adenomatous polyposis coli knockout (Apc-KO) intestines, and revealed subtype-specific interactions linked to clinical classifications.

Lei Tang, Kang Tian, Xiao-Lei Fu et al. · 0 citations

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