Ef fi cient epigenetic editing of the zebra fi sh slc45a2 gene using the CRISPR/dCas9 system and tandem guide RNAs
It is found that microinjection of CRISPR/dCas9 with gRNAs targeting the CpG island around the transcription initiation site led to a marked reduction in melanin synthesis, which indicated that epigenetic gene editing technology is needed for gene silencing, which will lay the foundation for the application and promoti...
Shen Huang, †. MengfanWu, Yan Huang et al.
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