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Qinghua Cui

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Jul 2026

LC-SEPLM: long-range contact-supervised adaptation for sequence-only protein representation learning

LC-SEPLM (Long-range Contact-supervised ESM Protein Language Model), which adapts ESM2 with LoRA and long-range residue-pair contact supervision while retaining sequence-only downstream inference, supports residue-pair contact supervision as a bounded route for introducing structural information into protein sequence representations while preserving sequence-only inference.

Chen Wang, Boming Kang, Qinghua Cui · arXiv.org · 0 citations