Open access
Aug 2026
NUFIP1 gain of function promotes fibrotic remodeling and reveals a ZNHIT3-linked metabolic vulnerability in idiopathic pulmonary fibrosis models
Background Fibroblast activation and extracellular matrix deposition are central features of IPF, but the molecular programs that sustain pathogenic fibroblast states remain incompletely defined. NUFIP1 has been implicated in ribonucleoprotein biology and cellular stress responses, yet its role in pulmonary fibrosis is...
Yueyan Lou, Guo-Jun Qian, Zhi-Han Jiang et al.
· Frontiers in Immunology · 0 citations