Qing-Xian Ji

Discovery of potent salicylanilide derivatives as effective antimicrobial agents against multidrug-resistant gram-positive pathogens.

The increasing prevalence of multidrug-resistant bacteria underscores the need for antibacterial agents with mechanisms distinct from those of conventional antibiotics. Inspired by the amphiphilic organization and membrane-active properties of host defense peptides (HDPs), we synthesized 22 salicylanilide derivatives a...