Sep 2026
DONSON links tumor-cell survival to MIF-associated macrophage remodeling in small cell lung cancer
Qing-Wu Du, Rui Li, Ting Mei et al.
· Apoptosis · 0 citations
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Open access
Aug 2026
XPO1-mediated TRIM21 nuclear export reprograms TREM2+ macrophage polarization by targeting IRF3 to augment anti-PD-1 efficacy in small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive malignancy that responds poorly to immune checkpoint inhibitor (ICI) therapy, due to its immunosuppressive tumor microenvironment. Here, we analyse preclinical mouse tumor models and patient-derived SCLC samples and identify Exportin 1 (XPO1) as a regulator of immune suppr...
Qing-Wu Du, Ting-Ting Qin, Jing-Ya Wang et al.
· Nature Communications · 0 citations