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Author

Qing-Rong Xia

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Open access Sep 2026

Celecoxib Ameliorates Chronic Restraint Stress-Induced Depression-Like Behavior in Sprague-Dawley Rats

Introduction Chronic stress is associated with depressive-like behaviors, dysregulation of the hypothalamic-pituitary-adrenal axis, and changes in inflammatory signaling. Celecoxib is a selective cyclooxygenase-2 inhibitor that has been investigated as a potential adjunctive treatment for depression; however, its effec...

Yian Ling, Jing Li, Wan-Bin Liu et al. · 0 citations
Review Open access Sep 2026

β-hydroxybutyrate in depression: Neuropharmacological mechanisms and therapeutic potential.

The biosynthesis and transport of BHB is synthesized, the evidence linking BHB to depression across animal and human studies is critically evaluated, and the relative strength of the proposed neuropharmacological mechanisms are appraised.

Wan-Bin Liu, Xiu-Qing Cao, Yian Ling et al. · 0 citations
Open access Aug 2026

IL-1α and CRP as key inflammatory mediators linking neuropathic pain, anxiety, and depression in major depressive disorder

The findings highlight IL-1α and CRP as key inflammatory markers associated with the relationship between pain, anxiety, and depressive symptoms and suggest the potential relevance of inflammation-related pathways in the clinical assessment of pain within the context of MDD.

Cuizhen Zhu, Lin Cheng, Jian Cheng et al. · 0 citations

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