Author

Qingrong Li

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Open access Sep 2026

Structural basis of transcription of the hachimoji eight-letter alphabet by E. coli RNA polymerase

Expanded genetic alphabets with synthetic nucleotides can greatly increase the chemical diversity of nucleic acids, enabling new molecular functions. Because cellular transcription is executed by multi-subunit RNA polymerases, the compatibility of unnatural base pairs with this machinery is essential for engineering ex...

Qing-Rong Li, Hyo-Joong Kim, Yan Liu et al. · Nature Communications · 0 citations

Open access Jul 2026

Structural dynamics of RNA polymerase II throughout the nucleotide addition cycle

These findings define a comprehensive structural and dynamic framework for RNAPII NAC, yielding a “molecular movie” of RNAPII in action and revealing a fundamental principle by which the enzyme balances speed and fidelity through coordinated conformational dynamics.

Gangshun Yi, Qing-Rong Li, H. Holmberg et al. · Nature Communications · 1 citation