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Qing-Mei Liu

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Open access Oct 2026

Alpha-ketoglutarate ameliorates systemic sclerosis-associated fibrosis by restoring endothelial function.

Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by multi-organ fibrosis with limited therapeutic options. Using targeted metabolomics, we first observed that levels of alpha-ketoglutarate (α-KG), a key TCA-cycle intermediate, were paradoxically elevated in bleomycin-induced fibrotic lungs and...

Yan-Ting Wu, Shi-Kai Ye, Huan-Ling Chen et al. · 0 citations

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