Author

Qing-Hua Jiang

2 papers indexed here

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Open access Sep 2026

Coordinated cellular programmes distinguish responses to neoadjuvant PD-L1 blockade and potentiate combinatorial immunotherapy in ESCC.

BACKGROUND Programmed death ligand 1 (PD-L1) blockade offers new therapeutic options for oesophageal squamous cell carcinoma (ESCC); however, the underlying mechanisms and associated biomarkers that determine treatment response remain unclear. OBJECTIVE We delineate the mechanisms underlying the response and resistan...

Si Li, Ji-Yu Guo, Jian-Qun Ma et al. · Gut · 0 citations

Oct 2026

Single-cell transcriptome analysis reveals onco-fetal reprogramming with implications for drug resistance and clinical outcome.

Onco-fetal reprogramming of the tumor ecosystem induces fetal-like characteristics, leading to tumor growth and malignant progression. Here, we develop a robust computational pipeline to systematically identify onco-fetal (OF) cells, using single-cell transcriptomic data from corresponding fetal and tumor tissues acros...

Yong-Le Xu, Shao-Yi Chen, Zheng-Lin Lu et al. · Genome Research · 0 citations