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Qing-Feng Ruan

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Oct 2026

Prioritizing MMP8 as an exploratory therapeutic candidate in Parkinson's disease through proteome-wide Mendelian randomization and computational multi-omics integration.

BACKGROUND Parkinson's disease (PD) lacks disease-modifying therapies. We aimed to prioritize circulating proteins using multi-omics integration combining proteome-wide Mendelian randomization (MR) for discovery with network, structural, and single-cell evidence for prioritization. METHODS We performed proteome-wide...

Hong-Yuan Zhang, Jing Zou, Yan-Hong Zhao et al. · 0 citations

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