Open access
Sep 2026
Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis
The PIEZO1/SP1/STC2 axis is established as a pivotal mechanosensitive signaling pathway for MSC fate determination, offering novel molecular targets for mechanically optimized bone regenerative biomaterials.
Shuo Zhang, Si-Teng Li, Wen-Zhong Chen et al.
· Advancement of science · 0 citations