Open access
Oct 2026
Highly effective viral RdRP translocation hindrance by the remdesivir nucleotide
Abstract Nucleoside/nucleotide analogs (NAs) typically interfere with substrate selection and catalysis steps of polymerase nucleotide addition cycle (NAC), thereby affecting polymerase catalytic efficiency. In contrast, their interference with post-chemistry translocation is rarely considered in rational design, partl...
Rui Li, Qiang Shao, Mei-Hua Wang et al.
· Nucleic Acids Research · 0 citations