Author

Qifeng Sheng

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Open access Aug 2026

WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M6A‐Mediated Regulation of CSF1R Signaling in Estrogen‐Deficient Osteoporosis

ABSTRACT Osteoporosis, characterized by imbalanced bone homeostasis, is driven by excessive osteoclast‐mediated bone resorption, yet the epitranscriptomic regulation via m6A modification remains unclear. Here, we identify WTAP, a component of the m6A methyltransferase complex, as a critical negative regulator of osteoc...

Chen Shen, Xin Liu, Gao-Ran Ge et al. · Advancement of science · 0 citations

Aug 2026

Microenvironment-responsive dual-network hydrogel with stage-adapted release promotes diabetic bone regeneration.

Diabetic bone regeneration is severely hindered by hyperglycemia-induced inflammation and microangiopathy. In this case, conventional drug strategies show limited efficacy. Inspired by the natural polyphenol structure, this study engineered a dual-network self-assembled hydrogel with glucose responsiveness and stage-ad...

XiaoQian Lu, Qifeng Sheng, Qi-Han Wang et al. · Biomaterials · 0 citations