Jul 2026
Identifying and reprogramming softness-driven cancer stem-like cells overcomes CAR-T cell resistance in solid tumours.
To render these resistant cells targetable, the mechano-recorder is rewired into a mechano-reprogrammer by replacing the fluorescent output with the clinically validated antigen CD19, enabling softness-responsive cells to be recognized by CD19-directed T cells.
Yunjia Qu, Yuxuan Wang, Linshan Zhu et al.
· Nature Biomedical Engineerin... · 2 citations