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Qiaochu Chen

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Open access Aug 2026

Distinct multi-omics signatures of clinical subgroups of type 2 diabetes define heterogeneous responses to an insulin sensitizer

Type 2 diabetes (T2D) subgroups defined by clinical variables differ in disease progression and treatment response. To uncover potential molecular drivers of this heterogeneity, we performed a multi-omics analysis of 826 drug-naïve T2D patients from two phase 3 trials of the insulin sensitizer chiglitazar. Here we show...

Ze-Hui Cao, Ruo-Lan Zhang, Hao-Nan Chen et al. · 0 citations
Open access Aug 2026

Plasma titration provides a physical ruler for cross-platform proteomics

Plasma proteomics is expanding across platforms and cohorts, and integrating these data for AI demands comparability at the protein level, not merely concordant associations1,2. Affinity and MS platforms use distinct probes (antibodies, aptamers, or peptides) and signal readouts, yielding contradictory cross-platform r...

Yaqing Liu, Haiyan Wang, Yutong Zhang et al. · 0 citations
Preprint Aug 2026

SimP: Unifying Syntax- and Semantic-Guided Techniques for Efficient Program Reduction

SimP is a program reduction framework that combines traditional reduction with LLM-based syntax- and semantic-guided reduction, and synergistically combines rule-based and LLM-based reduction stages to optimize the reduction performance.

Yewei Xiong, Xiangyu Gao, Qiaochu Chen et al. · 0 citations

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