Type 2 diabetes (T2D) subgroups defined by clinical variables differ in disease progression and treatment response. To uncover potential molecular drivers of this heterogeneity, we performed a multi-omics analysis of 826 drug-naïve T2D patients from two phase 3 trials of the insulin sensitizer chiglitazar. Here we show...
Plasma proteomics is expanding across platforms and cohorts, and integrating these data for AI demands comparability at the protein level, not merely concordant associations1,2. Affinity and MS platforms use distinct probes (antibodies, aptamers, or peptides) and signal readouts, yielding contradictory cross-platform r...
SimP is a program reduction framework that combines traditional reduction with LLM-based syntax- and semantic-guided reduction, and synergistically combines rule-based and LLM-based reduction stages to optimize the reduction performance.
Yewei Xiong, Xiangyu Gao, Qiaochu Chen et al.· 0 citations
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