Qiao Huang

Concurrent EGFR exon 19 deletion-insertion and germline BRCA1 alteration in KRAS-wild-type pancreatic ductal adenocarcinoma: A case report and review of therapeutic implications

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid malignancies, with a dismal prognosis and a 5-year overall survival rate of 5–10%. Owing to the absence of specific symptoms at early stages, the majority of patients are first diagnosed with already locally advanced or metastatic disease. Cons...