Microglia play essential yet poorly understood roles in brain development, including axon guidance, regulation of neurogenesis, and pruning of neuronal projections. Congenital hydrocephalus (CH), characterized by enlarged cerebrospinal fluid (CSF)-filled ventricles, is a leading cause of pediatric brain surgery, but it...
Phan Q. Duy, Benjamin C. Reeves, Huan-Xing Sun et al.· Journal of Clinical Investig...· 0 citations
Neurogenic bladder is one of the most disabling consequences of spinal cord injury (SCI), yet it remains unclear whether residual brain–bladder communication persists after injury and can be therapeutically strengthened. Here, we integrated analysis of a clinical SCI cohort with studies in a mouse model that recapitula...
Exome sequencing may complement surgical evaluation of children with sporadic CM1, particularly when accompanied by neurodevelopmental concerns, informing prognosis and family counseling, and implicating genetically encoded dysregulation of cerebellar development as a central disease mechanism.
Neel H. Mehta, Garrett Allington, Evan Dennis et al.· Brain : a journal of neurolo...· 0 citations
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