Author

Qian Xu

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Open access Sep 2026

Integration of ultra-widefield optical coherence tomography angiography images and clinical indicators for identifying early-stage diabetic retinopathy in type 2 diabetes

Background Diabetic retinopathy (DR) is a common microvascular complication of diabetes and a leading cause of irreversible vision loss among working-age adults, making early detection essential for preventing permanent visual impairment. This study aimed to identify early-stage DR in patients with type 2 diabetes mell...

Cong-Shu Zhang, Li Wang, Shi-Meng Huang et al. · Frontiers in Endocrinology · 0 citations

Open access Sep 2026

Hyperglycemia‐Induced Microglial CTSS Disrupts Blood‐Retinal Barrier Integrity via PAR2‐Dependent Downregulation of Endothelial MFSD2A

ABSTRACT Background Diabetic retinopathy (DR), a leading cause of blindness in diabetes, involves dysregulated neuroimmune crosstalk. While microglial activation and endothelial dysfunction are established in DR, the molecular mechanisms linking innate immunity to blood‐retinal barrier (BRB) breakdown remain elusive. M...

Cheng-Ye Xu, Hong-Xue Li, Qian Xu et al. · CNS Neuroscience & Therapeut... · 0 citations

Open access Aug 2026

Targeting NIK-mediated microglial polarization: a novel therapeutic strategy for diabetic retinopathy

Diabetic retinopathy (DR) is a sight-threatening microvascular complication characterized by blood-retina barrier (BRB) disruption. While inflammation is central to early DR, the role of the non-canonical NF-κB pathway remains poorly understood. We established a murine DR model and performed RNA-seq. Retin...

Hong-Xue Li, Qian Xu, Cheng-Ye Xu et al. · Journal of Translational Med... · 1 citation · ⚡1