The Catalytic Oxidative Cyclization Synthesis of Isochromanoindolenines by Multicopper Oxidase in a Microflow System
Herein, we disclose a microflow system-mediated oxidative cyclization process catalyzed by multicopper oxidase, employing 2,3-dihydroxybenzoic acid and a range of substituted tetrahydrocarbazoles to afford structurally complex isochromanoindolenines. The reaction proceeds under mild conditions without the need for ex...