Author

Qian Guo

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Review Open access Aug 2026

Liver microenvironment-driven immunosuppressive niche in colorectal cancer liver metastasis and its therapeutic remodeling

Colorectal cancer liver metastasis is the most frequent and clinically important pattern of distant spread in colorectal cancer and remains a major determinant of poor prognosis and treatment failure. In the era of immunotherapy, liver metastasis has emerged as an organ-specific barrier to effective antitumor immune re...

Zi-Jing Liu, Jia Liu, Sheng-Shan Xu et al. · Frontiers in Immunology · 0 citations

Open access Sep 2026

System biology analysis reveals circadian rhythm disorder associated with development and progression in colorectal cancer

The ClockProCRC system is developed and validated, which detects and quantifies intrinsic circadian misalignment in CRC and elucidates how circadian misalignment drives CRC progression trajectories, shapes clinical phenotypes, regulates disease manifestations, and reshapes the tumor microenvironment.

Shi-Qian Zhang, Shan-Shan Cai, Nai-Jing Hou et al. · npj Precision Oncology · 0 citations