SYVN1-Mediated Degradation of SHMT2 Drives Tubular Injury Progression via Metabolic Reprogramming.
Serine hydroxymethyltransferase 2 (SHMT2) is a key mitochondrial enzyme involved in one-carbon metabolism, but its regulation and functional significance in acute kidney injury (AKI) remain unclear. To determine whether SHMT2 downregulation contributes to tubular injury and to elucidate the underlying molecular mechani...