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Author

Qi Zhang

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Open access Aug 2026

Chrysosplenetin-induced TMED3 aggregation triggers unfolded protein response in pancreatic cancer

Pancreatic cancer (PC) continues to demand urgent therapeutic innovation given its limited treatment options. Here, through phenotypic screening of a natural product library followed by systematic validation, we identified chrysosplenetin (CHR) as a bioactive compound with anti-PC activity. Transcriptomic profiling and...

Zhe Zhang, Ning-Na Weng, Xuan-Hao Gu et al. · 0 citations
Sep 2026

UniCure: A multi-modal model for predicting personalized cancer therapy response.

UniCure is presented, a multi-modal model that combines biological and chemical foundation models to predict drug-induced transcriptomic responses across diverse cell and tissue contexts, enabling individualized drug ranking.

Ze-Xi Chen, Saisai Tian, Jia-Zheng Pei et al. · 0 citations

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