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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Qi-Xuan Gu

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Review Open access Sep 2026

CD4+ cytotoxic T cells: context-dependent effectors in health and disease

Cytotoxic CD4 + T cells (CD4 + CTLs) have been identified as a specialized effector population characterized by potent cytotoxic machinery, including granzymes, perforin, and the Fas/FasL pathway, that enables the direct killing of MHC-II-expressing target cells. In addition to their classical helper function,...

Hao-Yang Yu, Jia-Xin Liang, Qi-Xuan Gu et al. · 0 citations

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