Qi-Wen Gan

Loss of the tumor suppressor p53 generates a signaling gradient that drives epithelial clonal expansion.

Although tumor protein p53 (TP53) mutations are among the most common lesions in epithelial cancers, how p53 loss drives unrestrained clonal expansion remains unclear. Working with mouse epidermis, we found that p53 suppresses clonal expansion by limiting progenitor self-renewal. Integrating chromatin immunoprecipitati...