Author

Qi Wang

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Open access Oct 2026

Colorectal cancer cell-derived arginine drives SMS-mediated spermine synthesis and PI3K-AKT-mTOR-dependent M2 polarization of tumor-associated macrophages

Colorectal cancer (CRC) often exhibits severe tolerance to immunotherapy due to the highly immunosuppressive nature of the tumor microenvironment (TME), with the polarization of tumor-associated macrophages (TAMs) toward the pro-tumor M2 phenotype playing a key role. Arginine (Arg), as a core precursor for the synt...

Qi Wang, Peng-Fei Bi, Chun-Lin Wang et al. · Scientific Reports · 0 citations

Open access Sep 2026

Local lactate-driven H3K18 lactylation impairs anti-influenza immunity through NRF2-dependent dendritic cell dysfunction.

Metabolic alterations are increasingly recognized during influenza virus infection, but how local lactate accumulation shapes antiviral immunity remains poorly characterized. By integrating time-series targeted energy metabolomics, single-cell RNA sequencing, flow cytometry, and functional perturbation, we show that in...

C. Lyu, Jiu-Yang Xu, Yu-Lin Zhang et al. · Cell Reports · 0 citations