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Aug 2026

Child-to-adult body size trajectories and risk of rheumatoid arthritis: the mediating role of metabolic unhealthiness, low-grade inflammation, and the modifying effect of genetic susceptibility.

OBJECTIVE To investigate the association between body size changes from childhood to adulthood and rheumatoid arthritis (RA), considering the roles of metabolic unhealthiness, low-grade inflammation, and genetic susceptibility. METHODS Data from the UK Biobank on 482,264 RA-free participants were divided into nine ca...

Xing-Yu Wan, Wei Huang, Yi-Xu Wang et al. · 0 citations
Open access Sep 2026

Proteomic signatures of systemic inflammation in aging, multimorbidity, and mortality.

BACKGROUND Chronic low-grade inflammation is central to biological aging, but routine inflammatory biomarkers capture limited molecular heterogeneity. We aimed to develop a proteomic inflammaging score (PIS) and evaluate its practical utility. METHODS In 40,471 England participants from UK biobank, we used LASSO to i...

Zhou Jiang, Dan-Yang Ling, Zi-Wei Chen et al. · 0 citations

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