Author

Qi-Shui Ou

3 papers indexed here

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Oct 2026

B-194 Bile Acid Metabolomics Reveals Distinct Immunometabolic Niches and Enables Accurate Diagnosis of AQP4-IgG–Seronegative NMOSD

Distinguishing neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS) remains clinically consequential, particularly in patients seronegative for anti–aquaporin-4 IgG (AQP4-IgG), for whom objective biomarkers are limited. Because bile acids (BAs) mediate gut microbiota–host signaling and immu...

Qi-Shui Ou, Zi-Xin Chen · Clinical Chemistry · 0 citations

Oct 2026

LNA Blocker-Enhanced Multiplex Chip-Based Digital PCR for Ultrasensitive Quantification of Liver-Specific DNA Methylation in Plasma

Sensitive and selective quantification of rare methylated DNA in plasma remains a major analytical challenge. For methylation targets located in CpG-sparse regions, bisulfite conversion produces only subtle sequence differences between methylated and unmethylated alleles, thereby hindering selective amplification. He...

Yan-Ping Lan, Xin Yang, Tian-Bin Chen et al. · Analytical Chemistry · 0 citations

Open access Sep 2026

Humanin Attenuates Inflammatory Liver Injury and NF-κB Activation During Systemic Hypervirulent Klebsiella pneumoniae Infection

Hypervirulent Klebsiella pneumoniae (hvKP) causes invasive infections, including bloodstream infections and liver abscesses, and dysregulated host inflammation may exacerbate liver injury. We investigated whether pretreatment with Humanin, a mitochondria-derived anti-inflammatory peptide, could attenuate hvKP-associate...

Yi-Ming Zhong, Dina Haishaer, Wei-Dong Cai et al. · Pathogens · 0 citations