Genome foundation models hold great potential for advancing biological research, but modeling diverse complex genomes and generating controllable genome-scale sequences remain challenging. We present DeepD, a phylogeny-informed sparse mixture-of-experts model operating at single-nucleotide resolution over a 1-million-t...
Bei-Bei Xin, Zi-Jian Wang, An Yu et al.· bioRxiv· 0 citations
The role of vaginal microbiota dysbiosis in the progression of human papillomavirus (HPV) infection is increasingly recognized. Yet, the factors determining why only a minority of infections persist and evolve into clinically significant disease remain poorly defined. From a large screening cohort of 4572 women, we...
Qi Sun, De-Wen Zhu, Peng Wang et al.· npj Biofilms and Microbiomes· 0 citations
Overall, MmALS represents a data-efficient active learning framework for protein evolution, advancing computational enzyme design by enabling accurate optimization under limited experimental sampling.
Chenlu Zhu, Yu-Cheng Guo, Yu-Jie Yang et al.· ACS Catalysis· 0 citations
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