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Open access Oct 2026

Camellioside A Engages SIRT3 to Promote FOXO3-PINK1/Parkin Dependent Mitophagy and Attenuate UVB-Induced Skin Photoaging.

Chronic ultraviolet B (UVB) irradiation is a principal driver of skin photoaging, characterized by oxidative stress, mitochondrial dysfunction, fibroblast senescence, and extracellular matrix degradation. Although Camellia chekiangoleosa shows potential for anti-photoaging applications, its bioactive constituents and u...

Hong-Qi Gao, Si-Jia Feng, Jun-Qi Wang et al. · 0 citations
Open access Sep 2026

Drimane-Pyrone-Type Meroterpenoids and Co-Isolated Compounds from the Deep-Sea Fungus Penicillium rubens MABC05 and Their Anti-Ferroptotic and Cytotoxic Activities

Ferroptosis is a critical driver of tubular necrosis, and its effective inhibition holds significant potential for mitigating renal injury. In this study, chemical investigation of the strain Penicillium rubens MABC05 yielded nine drimane-pyrone-type meroterpenoids (1–9), including six previously undescribed analogues,...

Ling-Yan Liu, Xin-Jia Yang, Cai-Xia Hu et al. · 0 citations
Aug 2026

Arglabin targets a non-canonical NLRP3/CCR2 axis to suppress MDSC infiltration and potentiates anti-PD-1 immunotherapy in hepatocellular carcinoma.

It is demonstrated that Arg suppresses HCC progression in syngeneic murine models by reducing MDSC infiltration and promoting CD8+ T-cell accumulation, providing a strategy for reversing immunosuppression and potentiating immunotherapy.

Di Kang, Jun-Yuan Duan, Qi Lv et al. · 0 citations

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