Open access
Sep 2026
Single-cell RNA-seq and machine learning identify HMGN2 as a lactylation-associated hub gene in heart failure
Heart failure (HF) is a diverse condition characterized by dysregulated lactate metabolism and histone lactylation, which may contribute to maladaptive cardiac remodeling. However, the cell type-specific mechanisms underlying these processes remain poorly understood. To address this gap, we integrated single-cell RNA s...
An-Zhen Xu, Yan-Bo Li, Qing Gong et al.
· PLoS ONE · 0 citations