Case report
Open access
Oct 2026
Case Report: Isolated leptomeningeal relapse after systemic control in PALB2-altered pancreatic cancer
Background Leptomeningeal metastasis (LM) is an uncommon manifestation of pancreatic ductal adenocarcinoma (PDAC) and has a median survival of only 1–2 months after diagnosis. Isolated LM after prolonged extracranial disease control is particularly rare and may be overlooked when systemic imaging results look stable. C...
Jian Yuan, Yang-Xian Xu, Qi-Hao Zhou et al.
· Frontiers in Medicine · 0 citations