Monitoring Liraglutide Oligomeric Interconversion and Fibril Dissociation through High-Pressure NMR Spectroscopy.
Aggregation and conformational dynamics are key attributes influencing the quality of peptide and protein therapeutics, yet the oligomerization pathways that underlie these behaviors remain difficult to characterize with conventional analytical tools. Here, we establish high-pressure nuclear magnetic resonance (HP-NMR)...