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Review Open access Oct 2026

Multifunctional hydrogel scaffolds for endogenous osteochondral regeneration

Osteochondral defects, frequently resulting from trauma, infection, or degenerative joint disease, present a significant clinical challenge due to their limited intrinsic healing capacity. Conventional cell-based therapies face limitations including immune rejection, high costs, and regulatory hurdles. Endogenous tissu...

Ling Zhang, Xuan Liu, Jin-Ping Liang et al. · 0 citations
Sep 2026

Notoginsenoside R1 attenuates post-ischemic pyroptosis: a novel CKLF1-endoplasmic reticulum stress pathway-mediated mechanism.

BACKGROUND Ischemic stroke induces neuronal pyroptosis driven by excessive endoplasmic reticulum (ER) stress, which exacerbates secondary brain injury. Notoginsenoside R1 (NGR1) has demonstrated neuroprotective properties; however, whether its mechanism involves the modulation of chemokine-like factor 1 (CKLF1)-mediate...

Han-Long Wang, Yang Sun, Sha-Sha Liu et al. · 0 citations

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