Qi Chen

A Novel Homozygous ZPBP Frameshift Variant Is Associated With Severe Acrosomal Structural Abnormalities in Asthenoteratozoospermia.

BACKGROUND Experimental disruption of Zpbp homologs in mice causes defective acrosomal biogenesis and male infertility. Human evidence remains limited to a small number of association-based or case-level reports linking ZPBP alterations to abnormal sperm-head or acrosomal phenotypes, without integrated characterization...