Background and purpose: Malaria remains a formidable global healthcare challenge due to emerging drug-resistant Plasmodium spp., underscoring the urgent need for novel antimalarial scaffolds. Thiolactomycin, a FAS-II inhibitor, is a promising lead for structural optimization. This study aims to design, synthesize, and...
Shaik Azeeza, M. Malik, Q. M. Jamal et al.· Research in Pharmaceutical S...· 0 citations
The global food system is under growing strain to deliver sufficient high-quality protein for a rising population, while curbing environmental degradation, tackling climate change, and maintaining long-term food security. Conventional livestock production is a major source of greenhouse gas emissions, excessive land an...
Sadaqat Ali, Benish Ali, K. Ahmad et al.· Frontiers in Nutrition· 0 citations
This integrated ML-to-simulation workflow prioritizes structurally novel candidate hits with predicted ALK inhibitory activity and provides an effective strategy for scaffold discovery and hit prioritization.
M. Haque, Q. M. Jamal, K. Ahmad et al.· Pharmaceuticals· 0 citations
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