Open access
Aug 2026
Regulated HSPG Signaling Directs Epicardial Behavior to Support Cardiac Formation
It is shown that epicardial SULF1 dynamically regulates HSPG sulfation to fine-tune the magnitude and duration of signaling to impact cell fate and cardiac morphogenesis, highlighting, for the first time, essential fine-tuning of HSPG-dependent signaling to modulate key processes in heart formation.
A. Redpath, Irina-Elena Lupu, Louis Haffreingue et al.
· Circulation Research · 0 citations