Open access
Aug 2026
Humanized Anti-PD-1 Antibodies Generated Using The Conditional Kernel-Elastic Autoencoder
A machine learning-based approach to evolve new anti-PD-1 antibodies within a chemically informed latent space using a conditional kernel-elastic autoencoder (CKEA) between nivolumab and pembrolizumab to preserve favorable therapeutic features while exploring variants with different potency.
Yuanjun Shi, Haote Li, Pulan Liu et al.
· bioRxiv · 0 citations