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Pu-Min Zhang

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Open access Sep 2026

α-Herpesviruses exploit host ssDNA gap prevention pathways for GC-rich genome replication and reactivation.

Many α-herpesviruses, such as herpes simplex virus type 1 (HSV-1) and pseudorabies virus, possess GC-rich genomes prone to forming G-quadruplex (G4) structures. However, the impact of these G4 structures on viral genome maintenance is unknown. Here, we demonstrate that G4s impede lagging strand DNA synthesis in the vir...

Juan Zhang, Meng-Jiao Lan, Hui-Guo Fu et al. · 0 citations
Open access Aug 2026

OTUD5 maintains STAT1/2 stability and promotes IFNγ-driven intestinal inflammation

Using an intestinal epithelial cell -specific Otud5 KO mouse model, it is shown that Otud5 deficiency significantly alleviated the IFNγ-dependent colitis induced by dextran sulfate sodium, as evidenced by reduced weight loss and diminished infiltration of Ly6C+ inflammatory monocytes.

Huiyuan Guan, Changzhou Cai, Jiewei Wang et al. · 0 citations

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