Many α-herpesviruses, such as herpes simplex virus type 1 (HSV-1) and pseudorabies virus, possess GC-rich genomes prone to forming G-quadruplex (G4) structures. However, the impact of these G4 structures on viral genome maintenance is unknown. Here, we demonstrate that G4s impede lagging strand DNA synthesis in the vir...
Juan Zhang, Meng-Jiao Lan, Hui-Guo Fu et al.· Cell Reports· 0 citations
It is concluded that DDX3X promotes genome maintenance and cell viability following DSB formation through regulation of BIRDHs and sensitizes tumor cells to cisplatin in vitro and in vivo.
Wei Wu, Meng-Jiao Lan, Juan Zhang et al.· Cell Death and Differentiati...· 0 citations
Using an intestinal epithelial cell -specific Otud5 KO mouse model, it is shown that Otud5 deficiency significantly alleviated the IFNγ-dependent colitis induced by dextran sulfate sodium, as evidenced by reduced weight loss and diminished infiltration of Ly6C+ inflammatory monocytes.
Huiyuan Guan, Changzhou Cai, Jiewei Wang et al.· Journal of Biological Chemis...· 0 citations
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