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Open access Oct 2026

Formulation and Optimization of Sustained-Release Gastroretentive Microspheres of Vonoprazan Using Box– Behnken Design

Background: Vonoprazan is a novel potassium-competitive acid blocker (P-CAB) with potent acid-suppressive activity; however, its therapeutic efficacy may be limited by rapid gastric emptying. The present study aimed to formulate and optimize sustained-release gastroretentive microspheres of vonoprazan using the ionotro...

Nari Umarani, Kishore Kumar Hotha, P. Kulkarni et al. · 0 citations

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